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High Levels of a Common Anti-DNA Idiotype (16/6), a Genetic Marker for SLE

 

作者: Y. Shoenfeld,   S. Brill,   A. Weinberger,   J. Pinkhas,   D.A. Isenberg,  

 

期刊: Acta Haematologica  （Karger Available online 1986）
卷期: Volume 76, issue 2-3  

页码: 107-109

 

ISSN:0001-5792

 

年代: 1986

 

DOI:10.1159/000206031

 

出版商: S. Karger AG

 

关键词: Anti-DNA antibodies;Autoantibodies;Autoimmune diseases;Idiotypes;SLE

 

数据来源: Karger

 

摘要:

Six out of 8 healthy first-degree relatives of a patient with systemic lupus erythematosus (SLE) had very high serum levels of a common anti-DNA idiotype (16/6). In this family an additional sister developed SLE, and all members were heterozygous for C4 deficiency. Measurements of common autoantibody idiotypes may contribute to the understanding of the genetics of autoimmune diseases. They might be found useful in detecting healthy subjects prone to the development of an overt clinical state.

 

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