Direct effects of platelet activating factor (PAF) on cardiac function in isolated guinea pig heart
作者:
Marianne Tanniére,
Luc Rochette,
期刊:
Drug Development Research
(WILEY Available online 1987)
卷期:
Volume 11,
issue 3‐4
页码: 177-186
ISSN:0272-4391
年代: 1987
DOI:10.1002/ddr.430110305
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: platelet‐activating factor;isolated guinea pig heart;myocardial regional flow;radiolabelled microspheres technique;Ginkgo Biloba extract
数据来源: WILEY
摘要:
AbstractThe direct effects of platelet activating factor (PAF) (2.5 nM) on isolated guinea pig heart were studied: first, on Langendorff model perfused hearts, using the radiolabelled microspheres technique, we found that PAF reduced the myocardial flow homogenously. Secondly, using isolated “working” heart preparations, the direct effects of PAF on the coronary and aortic flows, heart rate, and systolic ejection volume were evaluated. PAF markedly reduced coronary and aortic flows. Systolic ejection volume (SEV) was significantly decreased and the reduction, which was maximal at 3 min, persisted at 20 min. Some of the direct cardiac effects of PAF were antagonized by addition of GBE to the medium (10 mg/l). These data demonstrate the direct effects of PAF on cardiac function. The possible of PAF in the mediation of the episodes of coronary spasm may be sugges
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