AbstractA comparison of the bioavailability of disulfiram (DSF) after administration of non‐effervescent Antabuse®tablets (CP Pharmaceuticals, UK) and Antabuse®effervescent tablets Antabus®(A/S Dumex, DK) has been made in two cross‐over studies.The first study included 6 volunteers who were given 400 mg DSF after an overnight fast. The bioavailability of DSF after administration of non‐effervescent was found to be only 27ff/o of that achieved with effervescent tablets.The second study included 24 volunteers who were given 800 mg DSF after a light standardized meal. The relative bioavailability of DSF after administration of non‐effervescent compared with effervescent tablets was found to be only 34%.In addition to the difference in bioavailability of DSF after administration of the two preparations, a considerable difference was seen between the two studies. A light meal seems both to increase the bioavailability of DSF and to reduce the interindividual variation. A two to threefold increase in the bioavailability of DSF was found.Thus, the bioavailability of DSF appears to depend on both the formulation (preparation) and the mode of administration. A lack of bioequivalence between the two investigated DSF preparations