Dlarrhea is common in the acute care setting, particularly among critically III patients. Factors that cause diarrhea are usually multifactorial; some of the most common Include medications, hyperosmolar or rapidly delivered tube feedings, atrophy of Intestinal epithelium or ischemic bowel, short bowel syndrome, pseudomembranous colitis, Infection (Salmonella and Shigella species), opportunistic Infections In patients with acquired Immunodeficiency syndrome and severe hypoproteinemia. This article reviews different types and mechanisms of diarrhea commonly encountered In acute care. It Includes current concepts of managing diarrhea, such as calculation of stool osmotic gap, Identification of medications that cause diarrhea, modification of enteral therapy, and the use of antisecretory agents. Nursing responsibilities and contributions In the collaborative assessment and clinical management of diarrhea are also explored.