A case of hepatocellular carcinoma developing from the left portion of the caudate lobe (Spiegel lobe) was reported. The resection of the Spiegel lobe is generally difficult without combined left lobectomy or extensive rotation of the liver. In this patient, it appeared particularly difficult since the liver could barely be rotated medially due to the markedly enlarged left lobe. However, surgery was successfully performed with minimal mobilization and rotation of the liver, by dissecting the short hepatic veins through the foramen of Winslow from the right side of the hepatoduodenal ligament.