Experimentally‐induced Autonomic NeuropathyBeneficial Effect of a Topical ACTH4–9Analogue on Oculomotor Nerve Regeneration
作者:
William Vandertop,
Willem de Vries,
Nicolette Notermans,
Cees Tulleken,
Willem Gispen,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 35,
issue 3
页码: 457-462
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: ACTH4–9analogue;Autonomic neuropathy;Melanocortins;Nerve regeneration;Neuropeptides
数据来源: OVID
摘要:
MELANOCORTINS, PEPTIDES RELATED to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH4–9analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH4–9analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery.
返 回