High-Dose Cytosine Arabinoside in Chronic Lymphocytic Leukemia: A Clinical and Pharmacologic Analysis
作者:
RobertsonL. E.,
HallRoy,
KeatingMichael J.,
EsteyElihu,
KantarjianHagop M.,
McLaughlinPeter,
HagemeisterFrederick B.,
PlunkettWilliam,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 10,
issue 1-2
页码: 43-48
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309147355
出版商: Taylor&Francis
关键词: CLL;cytosine arabinoside
数据来源: Taylor
摘要:
Twenty-seven patients with B-cell chronic lymphocytic leukemia (CLL) or a related lymphoid malignancy were treated with high-dose cytosine arabinoside (ara-C) at a dosage of 3 gm/m2administered over 2 hours every 12 hours at one to four doses per course, which were repeated at 4-week intervals. Median patient age was 60 years. Fifty-four percent of CLL patients had Rai stage III or IV disease and the median number of prior therapies was three. Two patients achieved a complete response, five had a partial response, and two had clinical improvement for an overall response rate of 33%. The median duration of response was 9 months. Myelosuppression and infection were the main toxicities. Intracellular levels of the active metabolite ara-C triphosphate varied among patients, but comparisons of pharmacokinetic parameters revealed no significant differences between responders and non-responders. We conclude that high-dose ara-C has modest activity in CLL and that its use in combination with other agents in the treatment of CLL is warranted.
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