Synthesis of deuterium labeled C19‐Δ16steroids
作者:
R. H. Thompson,
A. M. Pearson,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1982)
卷期:
Volume 19,
issue 1
页码: 47-59
ISSN:0362-4803
年代: 1982
DOI:10.1002/jlcr.2580190108
出版商: John Wiley&Sons, Ltd.
关键词: Androst‐16‐enes;deuterium;sex odor in pigs
数据来源: WILEY
摘要:
AbstractDeuterium labeled forms of 5α‐androst‐16‐en‐3‐one, 3α‐hydroxy‐5α‐androst‐16‐ene, 3β‐hydroxy‐5α‐androst‐16‐ene, 3β‐hydroxy‐5, 16‐androstadiene and 4, 16‐androstadien‐3‐one were prepared to serve as internal standards in quantitative analysis of C19‐Δ16steroids by mass spectrometric reverse isotope dilution. In general, the methods used employed deuterium exchange of activated hydrogens adjacent to carbonyl carbons followed by reaction steps which isolated the newly incorporated deuterium. Removal of any remaining exchangeable deute
点击下载:
PDF
(404KB)
返 回