Prostacyclin Selectively Enhances Blood Flow in Areas of the GI Tract Prone to Stress Ulceration
作者:
HAROLD GASKILL,
KENNETH SIRINEK,
BARRY LEVINE,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1984)
卷期:
Volume 24,
issue 5
页码: 397-402
ISSN:0022-5282
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
This study assessed the effect of continuous infusion of prostacyclin on tissue blood flow throughout the GI tract to see whether small and large bowel flow was also affected. Twelve miniature swine were anesthetized, ventilated, and hemodynamically monitored. After stabilization each animal received either prostacyclin in buffer at 0.1 mcg/kg/minute for 3 hours or buffer alone (controls). Tissue blood flow was documented at baseline and at 1, 2, and 3 hours of prostacyclin infusion by injection of radiolabeled spheres. Prostacyclin infusion did not significantly affect mean arterial pressure, heart rate, or cardiac index compared to controls. At 3 hours tissue blood flow was significantly increased in the gastric mucosa (↑ 225%), small bowel (↑ 110%), cecum (↑ 260%), and transverse colon (↑ 160%) compared to controls. Prostacyclin may be an effective agent for prevention of ischemia in all areas of the GI tract prone to stress ulceration.
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