Antioxidant Actions and Early Ultrastructural Findings of Thiopental and Propofol in Experimental Spinal Cord Injury
作者:
Erkan Kaptanoglu,
Sibel Sen,
Etem Beskonakli,
H. Surucu,
Murvet Tuncel,
Kamer Kilinc,
Yamac Taskin,
期刊:
Journal of Neurosurgical Anesthesiology
(OVID Available online 2002)
卷期:
Volume 14,
issue 2
页码: 114-122
ISSN:0898-4921
年代: 2002
出版商: OVID
关键词: Spinal cord injury;Free radicals;Propofol;Thiopental;Electron microscopy
数据来源: OVID
摘要:
Thiopental and propofol are effective antioxidant agents. The current study was undertaken to examine the neuroprotective effects of a single intraperitoneal dose of thiopental and propofol. Effects of the drugs were evaluated by lipid peroxidation and ultrastructural findings. Fifty male Wistar rats were divided into five groups. Group 1 was the control group. Rats underwent laminectomy only, and nontraumatized spinal cord samples were obtained 1 hour after surgical intervention. All other rats sustained a 50-g/cm contusion injury by the weight drop technique. Group 2 rats underwent spinal cord injury alone, group 3 rats received 1 mL intralipid solution intraperitoneally immediately after trauma as the vehicle group, group 4 rats received a 15-mg/kg single dose of thiopental, and group 5 rats received a 40-mg/kg single dose of propofol intraperitoneally following the trauma. Samples from groups 2, 3, 4, and 5 were obtained 1 hour after injury. Lipid peroxidation was determined by measuring the concentration of malondialdehyde in the spinal cord tissue. The ultrastructure of the spinal cord was determined by electron microscopy. The contusion injury was associated with a rise in lipid peroxidation. Compared with the trauma group there was significant attenuation in lipid peroxidation of groups 4 and 5. Ultrastructural findings showed that the rats of group 4 sustained minor damage after spinal cord injury, but there was more evident damage in group 5 rats. These results indicate that thiopental decreases lipid peroxidation and improves ultrastructure, whereas propofol decreases lipid peroxidation without improving ultrastructure 1 hour after spinal cord injury in rats.
点击下载:
PDF
(2434KB)
返 回