Inhibitors of protein synthesis involved in memory disruption: A study of their effects on sympathetic ganglion isolatedin vitro
作者:
Paola Paggi,
Giovanni Toschi,
期刊:
Journal of Neurobiology
(WILEY Available online 1971)
卷期:
Volume 2,
issue 2
页码: 119-128
ISSN:0022-3034
年代: 1971
DOI:10.1002/neu.480020204
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe effect of puromycin, puromycin‐aminonucleoside, cycloheximide and acetoxycycloheximide has been tested on the function of the superior cervical ganglion of rat, by recording the postganglionic response evoked by preganglionic stimulation. All the compounds examined exerted a depressant effect, which was prompt and reversible with puromycin and its aminonucleoside, but slow and irreversible with the glutarimides. A correlation of these effects with inhibition of protein synthesis has been examined. The relevance of these findings for experiments on memory disruption reported in the literature is discusse
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