The Brn‐3c transcription factor contains a neuronal‐specific activation domain
作者:
Martin Smith,
Peter Morris,
David Latchman,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 851-856
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Brn-3c;Neuronal specific activation domain;POU family transcription factors;Transcriptional control
数据来源: OVID
摘要:
Brn-3a, Brn-3b and Brn-3c are closely related POU family transcription factors which are expressed predominantly in neuronal cells. Previously Brn-3a has been shown to activate a number of gene promoters in cotransfections carried out in different cell types, while Brn-3b inhibits the basal activity of these promoters. We show here that Brn-3c activates the same promoters as Brn-3a but only in co-transfections into neuronal cells and not in other cell types. This effect is dependent upon an N-terminal region of Brn-3c which acts as a neuronal cell specific activation domain when linked to a heterologous DNA binding domain. To our knowledge this is the first report of an activation domain with apparently neuronal specific activity.
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