Amperozide and conditioned behaviour in rats: potentiation by classical neuroleptics and α‐methylparatyrosine
作者:
Patrik Egbe,
Jörgen Engel,
Bo Gustafsson,
Erik Christensson,
期刊:
Pharmacology&Toxicology
(WILEY Available online 1990)
卷期:
Volume 66,
issue 1
页码: 18-21
ISSN:0901-9928
年代: 1990
DOI:10.1111/j.1600-0773.1990.tb01601.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractAmperozide, a new putatively antipsychotic compound, has been evaluated for its effect on conditioned avoidance response and food‐reinforced lever‐pressing. Given alone, amperozide was almost equipotent to clozapine, but less potent than haloperidol in both test models. It was found that there was a statistically significant synergism, in these two models, between amperozide and classical neuroleptics. Since amperozide is inactive in behavioural tests reflecting striatal dopaminergic mechanisms, the synergistic effect could be of great therapeutic value in the treatment of psychotic disord
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