Localized NMR spectroscopyIn vivo. Progress and problems
作者:
Jens Frahm,
Thomas Michaelis,
Klaus‐Dietmar Merboldt,
Wolfgang Hänicke,
Michael L. Gyngell,
Daisy Chien,
Harald Bruhn,
期刊:
NMR in Biomedicine
(WILEY Available online 1989)
卷期:
Volume 2,
issue 5‐6
页码: 188-195
ISSN:0952-3480
年代: 1989
DOI:10.1002/nbm.1940020504
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractMetabolites in brain and muscle of normal human volunteers have been studied by localized1H and31P NMR spectroscopyin vivo.Localization was achieved by means of stimulated echo (STEAM) sequences for both water‐suppressed1H NMR (TE = 20 ms) and31P NMR (TE = 3 ms). Volumes‐of‐interest and measuring times selected for brain spectroscopy were 8 mL and 6.5 min for1H NMR and 125 mL and 13 min for31P NMR, respectively. General problems relating to spatial localization, spectral resolution, and quantitation ofin vivoNMR data are discussed with respect to the nucleus and organs under investigation. They are correlated to studies of tissue extracts obtained at field strengths of 2.35 T (Bruker Biospec) and 7.0 T (Bruker MSL 300). Human studies were performed at 2.0 T on a whole‐body research system (Siemens Ma
点击下载:
PDF
(1559KB)
返 回