Clofazimine-Mediated Enhancement of Reactive Oxidant Production by Human Phagocytes as a Possible Therapeutic Mechanism
作者:
Ronald Anderson,
Birgit M. Zeis,
Ingram F. Anderson,
期刊:
Dermatology
(Karger Available online 1988)
卷期:
Volume 176,
issue 5
页码: 234-242
ISSN:1018-8665
年代: 1988
DOI:10.1159/000248711
出版商: S. Karger AG
关键词: Clofazimine;Phagocytes;Reactive oxidants;Immunosuppression
数据来源: Karger
摘要:
Clofazimine, at concentrations within the therapeutic range (0.01–5 μg/ml), stimulated human polymorphonuclear leucocytes (PMNL) to generate increased amounts of reactive oxidants (RO) when activated with the tripeptide leucoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), calcium ionophore, phorbol myristate acetate and opsonised zymosan. Clofazimine per se did not activate the membrane-associated oxidative metabolism of PMNL, but rather primed these cells to hyperreact to the various stimuli. To investigate the therapeutic significance of these observations clofazimine was administered to patients with various chronic inflammatory diseases (lichen planus, discoid lupus erythematosus and rheumatoid arthritis) and generation of RO by FMLP-activated phagocytes was measured before and during clofazimine administration. A statistically significant potentiation of RO generation by FMLP-activated phagocytes was observed during clofazimine administration. Since RO are immunosuppressive and antimicrobial the therapeutic mechanisms of clofazimine may be related to pro-oxidative interactions of this agent with phagocyt
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