A Simple Electrochemical Method for the Quantitative Determination of Acetaminophen in Serum
作者:
Andrew Falkowski,
Robert Wei,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 13
页码: 1003-1012
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108081444
出版商: Taylor & Francis Group
关键词: Oxidative Amperometric Detection;Acetaminophen
数据来源: Taylor
摘要:
A simple electrochemical method for the determination of acetaminophen in serum is described. The eleotrode and associated electronics are simple, reliable, and inexpensive to build. The apparatus can be operated at a rate of 2–3 determinations per minute using only 10 μl serum per determination. The procedure includes extraction of acetaminophen in ethyl acetate and subsequent oxidative amperometric detection of the drug by a form of flow-injection analysis. The system parameters of buffer, pH, and redox potential have been optimized to permit measurement of less than 10 μg/ml of acetaminophen. The determination is linear over the range of 10–300 μg/ml with a C.V. of less than 3% for replicate analysis of the same sample.
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