Toxicity and metabolism of monoethylhexyl phthalate and diethylhexyl phthalate: A survey of recent literature
作者:
JohnA. Thomas,
SharonJ. Northup,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1982)
卷期:
Volume 9,
issue 1
页码: 141-152
ISSN:0098-4108
年代: 1982
DOI:10.1080/15287398209530149
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The literature dealing with monoethylhexyl phthalate (MEHP), the principal metabolite of di(2‐ethylhexyl) phthalate (DEHP), a widely used plasticizer, is discussed. MEHP has been shown to be moderately toxic and, following oral administration, undergoes ω‐ and ω ‐ 1 oxidation to yield the same metabolites as does DEHP. In plasma there is an equilibrium between MEHP absorbed to albumin and in free solution, whereas DEHP is bound to fipoproteins. Studies involving orally administered MEHP revealed that mild hepatic changes occurred but there was no bioaccumulation of the monoester. Studies of the rat and rabbit indicated that MEHP has no teratogenic effects.
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