Breath Hydrogen Reflects Canine Intestinal Ischemia
作者:
JAY PERMAN,
LAUREL WATERS,
MICHAEL HARRISON,
EDWARD YEE,
GREGORY HELDT,
期刊:
Pediatric Research
(OVID Available online 1981)
卷期:
Volume 15,
issue 9
页码: 1229-1233
ISSN:0031-3998
年代: 1981
出版商: OVID
关键词: breath hydrogen carbohydrate;absorption;ischemia intestinal;necrotizing enterocolitis
数据来源: OVID
摘要:
SummaryThe relationship between breath hydrogen excretion and intestinal ischemia was investigated in nine mechanically ventilated dogs under pentobarbital anesthesia. An ileal segment was isolatedin situ, ligated at each end, and insufflated with hydrogen. Expired air was collected at intervals. Blood volume was reduced 30% by three successive equivalent hemorrhages 10 min apart. Local bowel ischemia was produced by clamping the blood supply to the isolated segment for 10 min. Graded hemorrhage produced stepwise reductions in breath hydrogen concentration, to 77 ± 13, 66 ± 15, and 35 ± 8% (mean ± S.E.) of baseline after the first, second, and third hemorrhages, respectively. These reductions correlated highly (r= 0.84;P< 0.01) with declines in mean aortic blood pressure. Occlusion of blood supply caused a significant (P< 0.025) decrease in breath hydrogen concentration and excretion to 39 ± 14% of baseline. Termination of occlusion was followed within 2 min by a 7-fold increase in breath H2concentration above the original baseline, probably reflecting reactive hyperemia. Breath hydrogen measurements appear to reflect functional (hemorrhagic shock-induced) and mechanical (vascular occlusion induced) enteric ischemia in dogs.
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