Synthesis of the terminal trisaccharide sequence of the ganglioside GD3, α-D-Neup5Ac-(2→8)-α-D-Neup5Ac-(2→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→1)-Cer (2) was achieved by employing an α-(2→8) disialyl glycosyl donor (1). Condensation of1with the glycosyl acceptor6, propyl 4,6-O-benzylidene-β-D-galactopyranoside, gave the desired protected trisaccharide10(14%) as well as the elimination and hydrolysis products of6, compounds8and9respectively.O-Deacetylation and debenzylation of10gave the final trisaccharide11, as its propyl glycoside.