Fluorimetric Determination of Certain Phenothiazine Derivatives Using Eosin
作者:
N.A. Zakhari,
M. Rizk,
M.I. Walash,
F. Ibrahim,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 11
页码: 1405-1417
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066220
出版商: Taylor & Francis Group
关键词: Fluorimetry;Phenothiazine determination;Eosin
数据来源: Taylor
摘要:
Eosin reacts with phenothiazine derivatives in dichloroethane to give intense fluorescent compounds having their excitation maximum at 318 nm and emission maxima at 450, 460 and 465 nm for prochlorperazine dimaleate, thiethylperazine dihydrochloride and trifluoperazine dihydrochloride, respectively. Under the optimum conditions, samples of 1-10 μg ml−1could be determined rapidly with coefficient of variation less than 1.8 %. This fluorescence reaction was also applied successfully to the determination of phenothiazine drugs in some pharmaceutical preparations.
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