The Association of Antisocial Personality Symptoms with Marijuana Abuse/DependenceA Monozygotic Co-Twin Control Study
作者:
SCHERRER1,2 JEFFREY,
LIN2,3 NONG,
EISEN2,3 SETH,
GOLDBERG4,5 JACK,
TRUE1,2 WILLIAM,
LYONS6-8 MICHAEL,
TSUANG7-10 MING,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1996)
卷期:
Volume 184,
issue 10
页码: 611-615
ISSN:0022-3018
年代: 1996
出版商: OVID
数据来源: OVID
摘要:
This study examines the association of symptoms of lifetime antisocial personality disorder (ASP) with marijuana abuse/dependence in Vietnam-era veteran male monozygotic twin pairs. In 1992, 1,874 monozygotic twin pairs responded to a structured psychiatric interview that obtained data on lifetime history of drug use and ASP. Among randomly selected individuals from each twin pair, 8 of 10 ASP symptoms were significantly more prevalent in persons with a lifetime history of marijuana abuse/dependence compared with those who had never abused any drug (p<.001). Among 99 marijuana discordant twin pairs, however, only two ASP symptoms, “failure to conform to social norms” (odds ratio, 2.8; 95% confidence interval, 1.5 to 5.5) and “reckless regard of own or other's personal safety” (odds ratio, 2.4; 95% confidence interval, 1.0 to 5.4) were significantly increased in marijuana abusing/dependent twins compared with their nonabusing/nondependent twin brother. After adjustment for conduct disorder, alcohol abuse/dependence, and exposure to combat in Vietnam, only “failure to conform to social norms of lawful behavior” (odds ratio, 2.42; 95% confidence interval, 1.12 to 5.21) remained significantly increased in twins with marijuana abuse/dependence.
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