Modulation of cocaine-induced motor activity in the rat by opioid receptor agonists
作者:
A B Waddell,
S G Holtzman,
期刊:
Behavioural Pharmacology
(OVID Available online 1998)
卷期:
Volume 9,
issue 5
页码: 397-407
ISSN:0955-8810
年代: 1998
出版商: OVID
关键词: cocaine;locomotor activity;stereotypy;morphine;U69;593;DPDPE;rat
数据来源: OVID
摘要:
Selective opioid-receptor agonists were tested in combination with cocaine to determine the effect on the motor activity of rats. Cocaine produced dose-dependent increases in locomotor activity (distance traveled). The cocaine-induced increase in locomotor activity was potentiated by the selective δ-opioid receptor agonist [D-Pen2-D-Pen5]enkephalin (DPDPE). This potentiation was blocked by the general opioid receptor antagonist naltrexone, as well as by the selective opioid receptor antagonists β-FNA (µ-opioid receptor) and naltrindole (δ-opioid receptor). DPDPE also potentiated the increase in locomotor activity produced by the selective dopamine reuptake inhibitor GBR12909, but not that produced by the direct dopamine receptor agonist apomorphine. Cocaine-induced motor activity was potentiated by the activation of central δ- opioid receptors. The synergistic effect seen with δ-opioid receptor activation may involve a (β-opioid receptor component, and is probably mediated via a dopaminergic pathway.
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