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Microsatellite Polymorphisms for Chromosome 5 Bands q11.2-q13.3

 

作者: Robin Sherrington,   Baljinder Mankoo,   Mike Dixon,   David Curtis,   Gursharon Kalsi,   Georg Melmer,   Hugh Gurling,  

 

期刊: Human Heredity  （Karger Available online 1993）
卷期: Volume 43, issue 3  

页码: 197-202

 

ISSN:0001-5652

 

年代: 1993

 

DOI:10.1159/000154177

 

出版商: S. Karger AG

 

关键词: Chromosome 5;Schizophrenia;Spinal muscular atrophy;Polymorphism;microsatellite;Genetics

 

数据来源: Karger

 

摘要:

The genes for spinal muscular atrophy (SMA) and a possible subtype of schizophrenia (SCZD1) have been mapped to chromosome 5q11.2-q13.3. DNA markers have been mapped to 5q11.2–q13.3 using a hybrid cell line deleted for this region [Gilliam et al., Genomics 0.7. New polymorphic microsatelhtes were sequenced for D5S76, D5S125, D5S39, D5S127 and HEX-B. Two-point and multipoint analysis in non-CEPH pedigrees confirmed that the microsatelhtes were in tight linkage with each other. These new microsatelhtes will increase the efficiency of linkage analysis for these disor

 

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