Thirty-six patients with chronic hepatic diseases and ten normal control subjects with matching ages were studied by various clinical, laboratory and histopathologic means. Estimation of serum levels of thyroid hormones and thyroid stimulating hormones (TSH) showed that the average values of rT3, T4and TSH were higher in the group of chronic liver disease as compared to the controls. In the meantime, the average value of T3for those presenting with liver affection was lower than the controls. The severity of changes was most marked in the group of established cirrhosis followed by that of hepato-splenic schistosomiasic and chronic active hepatitis in that order of frequency.