The Prothrombin Gene
作者:
Ross T.A. MacGillivray,
David M. Irwin,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1986)
卷期:
Volume 16,
issue 3-4
页码: 227-238
ISSN:1424-8832
年代: 1986
DOI:10.1159/000215295
出版商: S. Karger AG
关键词: Prothrombin;Protein synthesis;Posttranslational modification;mRNA;Gene structure;Gene evolution
数据来源: Karger
摘要:
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues. Using bovine prothrombin cDNA as a hybridization probe, the genes coding for human and bovine prothrombin have been isolated and partially characterized. The organization of the prothrombin gene is similar, but not identical to the organization of the genes coding for the other vitamin-K-dependent clotting factors.
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