IMMUNE DYSFUNCTION ASSOCIATED WITH GRAFT‐VERSUS‐HOST REACTION IN MICE TRANSPLANTED ACROSS MINOR HISTOCOMPATIBILITY BARRIERSI. DEPRESSED ANTIGEN‐SPECIFIC ANTIBODY RESPONSES TO BACTERIOPHAGE øχ 174
作者:
BRIAN HAMILTON,
HANS OCHS,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 47,
issue 6
页码: 1061-1067
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
The effect of the graft-versus-host reaction in response to minor histocompatibility antigens on the antibody response to a T-dependent antigen was studied in four strains of mice. Lethally irradiated mice were transplanted with bone marrow plus graded numbers of spleen cells from H-2-compatible donors. Recipients of syngeneic bone marrow transplants and recipients of allogeneic bone marrow depleted of T cells made normal antibody responses to bacteriophage øχ 174 when immunized on day 28 (primary) and day 56 (secondary) after marrow transplantation. Recipients of allogeneic bone marrow plus spleen cells made only small amounts of specific antibody and failed to make IgG antibody after secondary immunization. The pattern of the depressed antibody response suggests that the primary mechanism of immune dysfunction in mice with the minor antigen GVHR is a lack of T helper cell function.
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