REPEATED ORAL BENZENE EXPOSURE ALTERS ENZYMES INVOLVED IN BENZENE METABOLISM
作者:
Davis H. Daiker, Mary Treinen Moslen, James B. Carr, Jonathan B. Ward,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1996)
卷期:
Volume 48,
issue 5
页码: 439-440
ISSN:0098-4108
年代: 1996
DOI:10.1080/009841096161177
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
Benzene is a known carcinogen and hematopoietic toxin in humans and experimental animals. The effect of acute, high-dose exposure to benzene on hepatic bioactivation and detoxication enzymes has been defined, while little is known about the effect of repeated, low-dose benzene exposure on these enzymes. Our objective was to determine whether repeated, oral benzene exposure alters enzymes involved in benzene metabolism. Specifically, we were concerned with cytochrome P-450-2E1, a bioactivation enzyme, and glutathione transferase and aldehyde dehydrogenase, two detoxifying enzymes. Female CD-1 mice were treated by gavage for 3 wk with benzene doses of 5 mg/kg (0.064 mmol/kg) or 50 mg/kg (0.646 mmol/kg) in corn oil. These doses of benzene produced 0.048 and 0.236 mumol muconic acid/d, respectively. We found that repeated exposure to 50 mg benzene/kg/d decreased P-450-2E1 activity by 34% and induced glutathione transferase activity by 30% without affecting aldehyde dehydrogenase activity. These changes in enzyme activities may serve a protective role against repeated exposure to benzene.
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