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A random horizon model for sequential clinical trials

 

作者: Gordon Simons,  

 

期刊: Sequential Analysis  (Taylor Available online 1989)
卷期: Volume 8, issue 1  

页码: 27-49

 

ISSN:0747-4946

 

年代: 1989

 

DOI:10.1080/07474948908836166

 

出版商: Marcel Dekker, Inc.

 

关键词: Bayesian;clinical trials;frequentist;Markov chain;martingale

 

数据来源: Taylor

 

摘要:

In response to a recent critique of a sequential clinical trials model, a version of the model is described for which the optimal stopping rule is explicitly soluble. The paper seeks to further the dialogue between practitioners and theoretician by describing, with the use of concrete formulas and graphics, a wide variety of the model's operating characteristics. Some should be of particular interest to practitioners and others should be of interest to theoreticians.

 

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