A random horizon model for sequential clinical trials
作者:
Gordon Simons,
期刊:
Sequential Analysis
(Taylor Available online 1989)
卷期:
Volume 8,
issue 1
页码: 27-49
ISSN:0747-4946
年代: 1989
DOI:10.1080/07474948908836166
出版商: Marcel Dekker, Inc.
关键词: Bayesian;clinical trials;frequentist;Markov chain;martingale
数据来源: Taylor
摘要:
In response to a recent critique of a sequential clinical trials model, a version of the model is described for which the optimal stopping rule is explicitly soluble. The paper seeks to further the dialogue between practitioners and theoretician by describing, with the use of concrete formulas and graphics, a wide variety of the model's operating characteristics. Some should be of particular interest to practitioners and others should be of interest to theoreticians.
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