首页   按字顺浏览 期刊浏览 卷期浏览 DEVELOPMENT OF REVERSED-PHASE CHIRAL HPLC METHODS USING MASS SPECTROMETRY COMPATIBLE MO...
DEVELOPMENT OF REVERSED-PHASE CHIRAL HPLC METHODS USING MASS SPECTROMETRY COMPATIBLE MOBILE PHASES

 

作者: KumarV. Penmetsa,   ChristopherD. Reddick,   SaulW. Fink,   BrentL. Kleintop,   GeraldC. DiDonato,   KevinJ. Volk,   StevenE. Klohr,  

 

期刊: Journal of Liquid Chromatography & Related Technologies  （Taylor Available online 2000）
卷期: Volume 23, issue 6  

页码: 831-839

 

ISSN:1082-6076

 

年代: 2000

 

DOI:10.1081/JLC-100101492

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

The majority of chiral HPLC separations are performed in the normal-phase mode using alcohol-modified hexane mobile phases. Normal-phase chiral HPLC methods are not routinely coupled with electrospray ionization mass spectrometry (ESI-MS) because of the mobile phase incompatibility. In this study, we investigated the use of ESI-MS compatible mobile phases for chiral HPLC methods. This would enable the sensitivity and selectivity of LC/MS to be applied to chiral HPLC analyses.

 

点击下载:  PDF (193KB)



返 回