The appetite suppressant d‐fenfluramine induces apoptosis in human serotonergic cells
作者:
Dietmar Bengel,
Krystyna Isaacs,
Armin Heils,
Klaus-Peter Lesch,
Dennis Murphy,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 2989-2993
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Appetite suppressant;Apoptosis;d-Fenfluramine;JAR cells;Neurodegeneration;Neurotoxicity;Serotonin transporter
数据来源: OVID
摘要:
FENFLURAMINE is an amphetamine analogue which has been widely used in the treatment of obesity. In rodents, non-human primates, and humans, fenfluramine is associated with some indices of neurotoxicity, as well as pulmonary hypertension and cardiac valve pathology. In the present study, d-fenfluramine was found to be cytotoxic to the serotonin (5-HT) transporter (5-HTT) expressing human placental choriocarcinoma cells. d-Fenfluramine caused DNA fragmentation and apoptosis. Apoptosis was not observed after the 5-HTT had been blocked by fluoxetine, indicating that intact 5-HTT function is required for d-fenfluramine to induce programmed cell death. These observations in a human cell line may reflect a possible mechanism associated with the risks of fenfluramine administration in several species, including humans.
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