Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres
作者:
Philippe Menei,
Jean-Pierre Benoit,
Michelle Boisdron-Celle,
Dominique Fournier,
Philippe Mercier,
Gilles Guy,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 34,
issue 6
页码: 1058-1064
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Biodegradable polymer;Drug delivery;Microspheres;Stereotaxy
数据来源: OVID
摘要:
CONTROLLED DRUG RELEASE in the central nervous system through an implantable polymeric vector has been developed in recent years. For this purpose, different polymeric devices composed primarily of synthetic biocompatible and biodegradable polymers have been investigated. The first polymeric devices developed were macroscopic implants (monolithic devices), which required open surgery for implantation. Microencapsulation methods, however, allow the production of microparticles or nanoparticles loaded with neuroactive drugs. Because of their size, these micro- or nanoparticles may be easily implanted by stereotaxy in discrete, precise, and functional areas of the brain without causing damage to the surrounding tissue. Presently, this method is most frequently applied in the fields of neuro-oncology and neurodegenerative diseases, but neurologically, the potential applications of drug targeting by stereotactic implantation of drug-loaded particles are legion.
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