Inherited thrombotic disorders: An update
作者:
Scott R. Florell,
George M. Rodgers,
期刊:
American Journal of Hematology
(WILEY Available online 1997)
卷期:
Volume 54,
issue 1
页码: 53-60
ISSN:0361-8609
年代: 1997
DOI:10.1002/(SICI)1096-8652(199701)54:1<53::AID-AJH8>3.0.CO;2-3
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: activated protein C resistance;homocysteinemia;factor V
数据来源: WILEY
摘要:
AbstractSignificant advances in identification of etiologies of inherited thrombosis have been recently reported. A point mutation in coagulation factor V (factor V Leiden) results in resistance to activated protein C and probably represents the most common genetic risk factor for venous thrombosis. A metabolic disorder, homocysteinemia, is now known to be an important risk factor for both arterial and venous thrombosis. Many patients with recurrent thrombosis will have more than one genetic risk factor identified. Recognition of these new disorders should permit a diagnosis to be achieved in at least half of patients evaluated for inherited thrombosis. Am. J. Hematol. 54:53–60, 1997 © 1997 Wiley‐Liss,
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