T Cell ReceptorβGene Polymorphism and Rheumatoid Arthritis
作者:
MalhotraUma,
ConcannonPatrick,
期刊:
Autoimmunity
(Taylor Available online 1992)
卷期:
Volume 12,
issue 2
页码: 75-77
ISSN:0891-6934
年代: 1992
DOI:10.3109/08916939209150312
出版商: Taylor&Francis
关键词: T cell receptor;restriction fragment length polymorphism;rheumatoid arthritis
数据来源: Taylor
摘要:
Susceptibility to rheumatoid arthritis is, in part, conferred by genetic factors. Previous studies have suggested that inheritance of a particular allele of a restriction fragment length polymorphism (RFLP) detected in the T cell receptorβ(TCRβ) gene complex is associated with rheumatoid arthritis (RA). We have specifically tested this hypothesis in ethnically and geographically matched populations of RA patients and controls. We were unable to confirm previous observations of a TCRβassociation with RA even after stratifying our study and control populations by HLA type.
点击下载:
PDF (269KB)
返 回