IL4andIL4R&agr; Genes Are Not Linked or Associated with Type 1 Diabetes
作者:
SHARON REIMSNIDER,
SARAH ECKENRODE,
MICHELE MARRON,
ANDREW MUIR,
JIN-XIONG SHE,
期刊:
Pediatric Research
(OVID Available online 2000)
卷期:
Volume 47,
issue 2
页码: 246-246
ISSN:0031-3998
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Previous studies have shown the immunoregulatory functions IL-4 in type 1 diabetes mellitus. Therefore, the genes involved in the IL-4 regulatory pathway are candidates for diabetes susceptibility genes. Here we have evaluatedIL4and the alpha subunit of the IL-4 receptor (IL4R&agr;) genes using the affected sibpair (ASP) and transmission/disequilibrium test (TDT). We analyzed 309 diabetic families from the United States and 87 families from various European countries. There was no evidence that either of these two genes are linked or associated with type 1 diabetes. Means by which IL-4 directed signals could indirectly alter diabetes susceptibility are proposed.
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