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Hydroxocobalamin Therapy of Cyanide Intoxication in Guinea Pigs

 

作者: Mark Posner,   Raymond Tobey,   Howard McElroy,  

 

期刊: Anesthesiology  （OVID Available online 1976）
卷期: Volume 44, issue 2  

页码: 157-160

 

ISSN:0003-3022

 

年代: 1976

 

出版商: OVID

 

关键词: Toxicity;cyanide; Biotransformation;nitroprusside; Anesthetic techniques;hypotensive;nitroprusside; Pharmacology;hydroxocobalamin

 

数据来源: OVID

 

摘要:

The efficacy of hydroxocobalamin (vitamin B12a) as a specific, nontoxic antidote in acute cyanide poisoning was tested. Guinea pigs receiving lethal intravenous NaCN injections were treated with either vitamin B12a or saline solution. There was a statistically significant antidotal effect of the vitamin. No toxic effect was observed with large doses of the vitamin.

 

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