Hyporeninemic Hypoaldosteronism, Sodium Wasting and Mineralocorticoid-Resistant Hyperkalemia in Two Patients with Obstructive Uropathy
作者:
Rene Pelleya,
James R. Oster,
Guido O. Perez,
期刊:
American Journal of Nephrology
(Karger Available online 1983)
卷期:
Volume 3,
issue 4
页码: 223-227
ISSN:0250-8095
年代: 1983
DOI:10.1159/000166717
出版商: S. Karger AG
关键词: Hyperkalemia;Salt wasting nephropathy;Interstitial nephritis;Pseudohypoaldosteronism;Renin;Aldosterone;Chronic renal failure;Type IV RTA;Mineral corticoids;Hypoaldosteronism
数据来源: Karger
摘要:
The renin-aldosterone system and tubular responsiveness to exogenous mineralocorticoid administration was evaluated in 2 hyperkalemic patients with obstructive uropathy. Both patients manifested marked renal sodium wasting and a modest inability to lower urine pH despite systemic acidosis. None of the abnormalities was corrected with supraphysiologic doses of mineralocorticoid. In addition, plasma renin and aldosterone levels were inappropriately low. Thus, both hypoaldosteronism and renal tubular resistance to mineralocorticoids coexisted in these patients. It is likely that an association between these abnormalities is more frequent than previously recognized.
点击下载:
PDF
(1076KB)
返 回