Haptoglobin subtypes have been determined in two population samples, one of them from the Pyrenean Valley of Pallars Sobirá in the province of Lérida and other from the Garrotxa region, province of Gerona. The obtained frequencies have been compared with other Pyrenean and European populations. Our results contrast with the absence of HP*2FF in the north-eastern district of the Pyrenees and suggest a more extensive distribution of this allele in European population