Interaction between Neuronal Amine Uptake and Prejunctional Alpha-Adrenergic Receptor Activation in Smooth Muscle from Canine Blood Vessels and Spleen
作者:
Robert R. Lorenz,
Paul M. Vanhoutte,
John T. Shepherd,
期刊:
Journal of Vascular Research
(Karger Available online 1979)
卷期:
Volume 16,
issue 3
页码: 113-125
ISSN:1018-1172
年代: 1979
DOI:10.1159/000158198
出版商: S. Karger AG
关键词: α-Adrenergic receptors;Adrenergic neurotransmission;Vascular smooth muscle;Nerve stimulation;Negative feedback
数据来源: Karger
摘要:
Experiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-3H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 × 10–6 M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K+ (40 mEq/l) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of 3H-norepinephrine or the displacement of 3H-norepinephrine by tyra
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