Evidence for Endothelium-Dependent Vasodilation of Resistance Vessels by Acetylcholine
作者:
Robert F. Furchgott,
Maria Helena Carvalho,
Mohammad T. Khan,
Kazuki Matsunaga,
期刊:
Journal of Vascular Research
(Karger Available online 1987)
卷期:
Volume 24,
issue 3
页码: 145-149
ISSN:1018-1172
年代: 1987
DOI:10.1159/000158689
出版商: S. Karger AG
关键词: Endothelium;Vasodilation;Resistance vessels;Hemoglobin;Endothelium-derived relaxing factor
数据来源: Karger
摘要:
In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of the vasculature with 0.2% collagenase, an enzyme capable of removing endothelial cells. In the perfused mesenteric arterial vasculature of the rat, vasodilation by ACh was markedly, though not completely, inhibited by hemoglobin (10 µM), an agent which can inactivate endothelium-derived relaxing factor (EDRF). These results suggest that a major component of vasodilation of mesenteric resistance vessels in rabbit and rat by ACh is mediated by EDRF
点击下载:
PDF
(672KB)
返 回