Three tobacco varieties were grown for three consecutive years on plots that were fertilized to produce a 2X2 factorial of soil acidity and soil fertility. Leaf samples and height measurements were taken periodically each year. The plant samples were analyzed for eleven elements. Rainfall differences among years provided information concerning the seasonal moisture effects on the treatment variables. Data presented show that the stage of growth, the soil fertility and acidity and the relative moisture stress affect tobacco height and the mineral composition of tobacco leaves. The information can be useful in assigning magnitude and direction for plant age and climatic interactions in practical diagnostic work.