BackgroundSentinel lymph node biopsy has been used for nodal staging of patients with melanoma and breast cancer. Initial studies suggest that this technique may be useful for selected pelvic tumors as well. The application of sentinel lymph node biopsy to vulvar, penile, endometrial, and colorectal cancers is discussed in this review.MethodsReview of the current literature regarding sentinel lymph node biopsy was performed.DiscussionRecent studies suggest that sentinel lymph node biopsy may provide accurate nodal staging information for a variety of pelvic malignancies and at the same time avoid the morbidity of complete lymphadenectomy for the majority of patients.ConclusionFurther study is necessary to document the accuracy of sentinel lymph node biopsy in vulvar, penile, endometrial, and colorectal cancers.