Effects of endothelin‐1 on hippocampal synaptic plasticity
作者:
Geoff Drew,
Christine Coussens,
Wickliffe Abraham,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1827-1830
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Calcium;Endothelin;Hippocampus;Long-term depression;Long-term potentiation;Picospritzer
数据来源: OVID
摘要:
WE examined the effects of puff application of endothelin (ET)-1 on the induction of long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) in hippocampal CA1 slices. ET-1 applied 2 min prior to tetanus blocked the induction of LTP, but facilitated the induction of heterosynaptic LTD. These ET-1 effects on synaptic plasticity were dose-dependent, and not due to a generalized depression of baseline responses. ET-1 did not alter NMDA receptor-mediated responses. These data provide the first evidence that endothelin modulates activity-dependent synaptic plasticity, and the potency of these effects suggests that endogenous ET-1 may play an important role in regulating memory storage processes.
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