A comparison of β‐functionalized ethyl groups for the protection of the phospho function in decathymidylate synthesis using a phosphite triester approach
作者:
C. A. A. Claesen,
R. P. A. M. Segers,
G. I. Tesser,
期刊:
Recueil des Travaux Chimiques des Pays‐Bas
(WILEY Available online 1985)
卷期:
Volume 104,
issue 7‐8
页码: 209-214
ISSN:0165-0513
年代: 1985
DOI:10.1002/recl.19851040706
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
AbstractA number of phosphorodichloridites (1) carrying various β‐functionalized ethyl protective groups were converted into their corresponding phosphoromorpholido chloridites (2). These were then reacted with 5′‐O‐(dimethoxytrityl)thymidine to give the pertinent phosphoromorpholidites (3). The applicability of these compounds in the synthesis of oligodeoxynucleotides on a solid support has been evaluated using the synthesis of the thymidine
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