&NA;The effect of perioperative blood transfusions on survival after curative resection for colorectal carcinoma was studied retrospectively on 270 patients with special emphasis on whole blood transfusion. Eightysix (32 percent) patients did not receive blood transfusions, whereas the remaining 110 (41 percent) received packed cells and 74 (27 percent) received at least 2 units of whole blood. The recurrence‐free and overall 5‐year survival rates for the transfused group were 58 and 57 percent, respectively, and for the non‐transfused group, 78 and 72 percent, respectively. These differences were highly significant (log rank test,P<0.001). The recurrence‐free and overall 5‐year survival rates for patients who received only whole blood or a combination of whole blood and packed cells was 51 percent, and of those who received only packed cells was 63 percent. The difference was not statistically significant (log rank test,P=0.08,P=0.35). Administration of more than 6 units of blood is attended with a significantly worse 5‐year disease‐free survival rate than administration of a smaller volume. The survival was not decreased if 6 or more units of whole blood were given. The authors conclude that perioperative blood transfusions have a significant detrimental effect on survival after curative resection for colorectal carcinoma. This effect is not enhanced by whole blood transfusions.