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HLA class I genes integrated into murine cells are inducible by interferon

 

作者: Frédéric Rosa,   Philippe P. Le Bouteiller,   Annie Abadie,   Zohair Mishal,   François A. Lemonnier,   Dominique Bourrel,   Michel Lamotte,   Jorge Kalil,   Bertrand Jordan,   Marc Fellous,  

 

期刊: European Journal of Immunology  （WILEY Available online 1983）
卷期: Volume 13, issue 6  

页码: 495-499

 

ISSN:0014-2980

 

年代: 1983

 

DOI:10.1002/eji.1830130612

 

出版商: WILEY‐VCH Verlag GmbH

 

数据来源: WILEY

 

摘要:

AbstractIn human cells treated with interferon, there is an increase in the amount of HLA‐A, B, C mRNA and, to a lower extent, membrane‐bound antigen. However, the mechanism of this mRNA enhancement is still unknown. Using mouse L cells transfected with a unique class I HLA gene, we were able to show that both the related HLA mRNA and protein are increased after murine but not human interferon treatment. Moreover, the discrepancy between interferon‐directed HLA mRNA and protein enhancement is also observed. The mouse transfected cells allowed us to study more precisely the origin of this discre

 

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