Site-Selective Cyclic AMP Analogs as New Biological Tools in Growth Control, Differentiation, and Proto-oncogene Regulation
作者:
ChoYoon Sang,
ClairTimothy,
TagliaferriPaierosandro,
AllyShamsia,
KatsarosDionyssios,
TortoraGiampaolo,
NeckersLeonard,
AveryThomas L.,
CrabtreeGerald W.,
RobinsRoland K.,
期刊:
Cancer Investigation
(Taylor Available online 1989)
卷期:
Volume 7,
issue 2
页码: 161-177
ISSN:0735-7907
年代: 1989
DOI:10.3109/07357908909038282
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe physiologic role of cyclic adenosine monophosphate (cAMP) in the growth control of a spectrum of human cancer lines, including leukemic lines, and v-rasHoncogene-transformed NIH/3T3 cells is demonstrated by the use of site-selective cAMP analogs. These cAMP analogs, which can select either of the two known cAMP binding sites of the cAMP receptor protein, induce potent growth inhibition, phenotypic change, and differentiation (leukemic cells) of cancer cells at micromolar concentrations with no sign of cytotoxicity. The growth inhibition parallels selective modulation of cAMP-dependent protein kinase isozymes, type I versus type II, and suppression of cellular proto-oncogene expression. Site-selective cAMP analogs thus provide new biological tools for investigating cell proliferation and differentiation and also for the improved management of human cancers.
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