Genetic Approach to Heterogeneity in Psychoses: Relationship of a Family History of Mania or Depression to Course in Bipolar Illness
作者:
George Winokur,
Raymond Crowe,
Arnold Kadrmas,
期刊:
Psychopathology
(Karger Available online 1986)
卷期:
Volume 19,
issue 1-2
页码: 80-84
ISSN:0254-4962
年代: 1986
DOI:10.1159/000284432
出版商: S. Karger AG
数据来源: Karger
摘要:
A specific family history or genetic background may be used to distinguish valid subgroups in patients who show similar symptoms. Also, a familial background may predict differences in other characteristics, i.e. course of illness, response to treatment or biological characteristics. Two hundred and fifty-one bipolar patients were separated according to their family history, 20 with a family history of mania with or without depression, 86 with a family history of depression only, and 145 with a family history of neither mania nor depression. The group that had a family history of mania was notable in that it showed more episodes of affective illness and was more likely to be readmitted to hospital. This difference in course suggests a familial association with multiple episodes and mania. In other respects than in course of illness, the groups separated by family history were similar.
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