KETAMINE-IN OIL-IN-WATER MULTIPLE EMULSION FOR PROLONGED DRUG RELEASE
作者:
S. Zheng,
R.L. Beissinger,
L.R. Sehgal,
D.T. Wasan,
期刊:
Journal of Dispersion Science and Technology
(Taylor Available online 1999)
卷期:
Volume 20,
issue 1-2
页码: 235-245
ISSN:0193-2691
年代: 1999
DOI:10.1080/01932699908943789
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A preparation of Ketamine [2-(Chlorophenyl)-2-(methylamino) cyclohexanone, C13H16ClNO, anesthetic agent] in oil in water multiple emulsion for prolonged drug release was formulated and evaluated. Ketamine, the cyclohexylamine, is used as a short-acting anaesthetic in humans and in some animal species [1]. Ketamine is poorly bound to plasma proteins and has a half-life of approximately 4 hours following intravenous injection [2]. Ketamine leaves the blood very rapidly to be distributed into the tissues with a high lipid solubility [2]. The recommended dosage of intravenous Ketamine is 2.5-20mg/kg [3]. The LD50 injected intraperitoneally in mice and rats is 100 times the intravenous and 30 times the intramuscular dose used in humans.
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