Effects of UFT (Mixed Compound of Tegafur and Uracil) on Cell Kinetics and Inhibition of Thymidylate Synthase in L1210 Ascites Tumor
作者:
KagawaYoshiyuki,
OhkuboToshiki,
HigashigawaMasamune,
IdoMasaru,
KakitoHideshi,
InagakiShoji,
KojimaMichio,
OoiKazuya,
SakuraiMinoru,
期刊:
Cancer Investigation
(Taylor Available online 1995)
卷期:
Volume 13,
issue 5
页码: 470-474
ISSN:0735-7907
年代: 1995
DOI:10.3109/07357909509024909
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Previous work in our laboratory showed that UFT (mixed compound of tegafur and uracil, molar ratio 1:4, respectively) caused the prolonged reduction of dTTP in L1210 leukemia cells in comparison with S-fluorouracil (S-FU). The purpose of this study was to assess the effect of UFT on cell cycle distribution and thymidylate synthase activity of a leukemia cell line as compared with 5-FU. UFT and 5-FU were orally given to BDFl mice bearing L1210 ascites tumor on day 3 after the tumor inoculation. Cell cycle distribution patterns at 24 hr after the drug administration showed a higher percentage of S phase in tumor cells treated with UFT than in those treated with 5-FU. Until 6 hr after the oral administration of the drugs, UFT inhibited the incorporation of [3H]deoxyuridine into DNA more long than 5-FU did. These results indicated that UFT has longer and stronger inhibitoiy effects on DNA replication than 5-FU in vivo under the employed experimental conditions (i.e., low and single doses of these fluorinated pyrimidines).
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