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Serotonin Uptake and Release by Platelets Adhering to Polyethylene

 

作者: R. Malmgren,   R. Larsson,   P. Olsson,   K. Rådegran,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  （Karger Available online 1979）
卷期: Volume 8, issue 6  

页码: 400-408

 

ISSN:1424-8832

 

年代: 1979

 

DOI:10.1159/000214330

 

出版商: S. Karger AG

 

关键词: Polyethylene;Adherent platelets;Serotonin uptake;Serotonin release

 

数据来源: Karger

 

摘要:

Heparinized human blood containing platelets labelled with 14C-serotonin and 51Cr was exposed to a polyethylene surface by rotation in Chandler loops. Both uptake of platelets on the surface and platelet aggregation in the blood occurred. More 14C- than 51Cr activity accumulated on the surface. It was demonstrated that this was due to an active uptake of 14C-serotonin by the surface-adherent platelets, which also retained their capacity to exert a release reaction.

 

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